Showing posts with label drug resistance. Show all posts
Showing posts with label drug resistance. Show all posts

Monday, April 20, 2015

Dangerous

Almost everyday, we at Kachhwa are reminded of how dangerous a disease, tuberculosis is turning out to be. Last week, we had a perfect example of how the disease has got itself entrenched in our communities and how helpless we have been in controlling the spread.

Mr. KK, a young man, about 25 years was brought to our outpatient with complaints of cough and fever since the last one year. He had already completed 8 months therapy of DOTS under the Revised National TB Program of the government. He had not improved. He had skipped medicines in between and therefore the 6 month long treatment took 8 months.

He did not remember whether he checked his sputum or not. He had only one X-Ray with him which he had taken 2 weeks back. The picture was bleak. 


2 weeks back someone told him that the persisting cough and fever was dangerous and therefore, he had been running from one hospital to the other – a whopping 4 places in 15 days.

The prescriptions are self explanatory. There is mention of MDRTB in at least 2 prescriptions. One place demanded a payment of 20000 INR which he could not cough up and therefore the concerned doctor crossed off the prescription.


Please note the crossed off medications.
Crossed off, as the patient could not afford 20,000 INR which the doctor demanded for admissiona and treatment.
The patient claims that this doctor guaranteed cure . . . 

The biggest problem is he is still not aware about the seriousness of the condition.

The challenges in Tuberculosis treatment remain quite basic –

1. Non-adherence to regular treatment
2. Late diagnosis and improper follow up
3. No mechanism in the ground level to detect resistance
4. Availability of anti-tuberculous medication as over the counter drugs
5. Mistrust of drugs provided through public healthcare

We’ve referred him to a tertiary care centre. I hope he gets the right management.

However, as each day progresses, we realise how dangerous MDRTB is slowly turning out to be. I wonder if the calculated prevalence rates are low . . .

I hope that we would be able to do at least the following in our Community Health Centres over the next year . . .

a. Drug sensitivity testing for all cases of tuberculosis

b. Curtail sale of anti-tuberculous medication over the counter. 

Till this is done, the situation can continue to become worse . . . 

Photo credit: StopTB

Wednesday, January 28, 2015

Menace

As most of us, tuberculosis is a major problem all over the country. 

One of the major issues in tuberculosis management is over the counter medications. Almost all anti-tuberculosis medicines are available very easily. 

Yesterday, in OPD, there was a boy who came with a peculiar skin lesion. We did a biopsy of the lesion. However, the boy also had a prescription written by someone on a piece of paper. He was told that this medicine is quite strong and should clear out the disease. 


He was smart to have not taken the prescribed treatment and opted to have it checked with a doctor. 

Unless, we can rein in such prescriptions, we are inviting avenues for emergence of Drug Resistant Tuberculosis. Of course, another cause of DRT is sub-optimal prescription doses of anti-tuberculosis medicines. 

The question is about any of us being serious about this issue. 

Monday, September 8, 2014

Antibiotic usage - Ofloxacin

I now live in a quaint small town called Barwadih. Along with the task of giving leadership to Community Health work at NJH, I help out in a small dispensary run by a congregation of the Catholic Church.

View from my window in Barwadih . . .
The local population is well serviced by a Community Health Centre of the government which is just next door as well as umpteen numbers of quacks in the surrounding villages. I understand that the total population of the region is around 50,000.

Most of the patients here usually come for a second opinion when they don’t feel well after a consultation elsewhere. Quacks are much preferred than the Community Health Centre where there are at least 3 doctors at any time of the day.

Over the last 2 weeks, I’ve been overwhelmed by the prescriptions that many of such patients received elsewhere where Ofloxacin in some form has been given. We noticed the same during our tenure at NJH too. Fevers of 1 day duration, sore throats, skin infections, suspected enteric fevers, urinary tract infections – all of them got ofloxacin.

The patient that prompted me to put in this post was one 10 week old boy who came with classical seborrhoeic dermatitis. He was prescribed Syrup Ofloxacin-Ornidazole and Ofloxacin ointment (I never knew there was an ointment preparation).

As far as I know Ofloxacin was an antibiotic we used when resistant strains of salmonella was suspected, a bad wound infection or after abdominal surgery.


I shall be much obliged if consultants in medicine and microbiology can comment on this unfettered usage of this antibiotic in remote areas of the country. I'm sure this is a easy recipe for antibiotic resistance . . .